Treatment and control of infectious diseases in humans and animals play a vital role in prevention of illness and death. Conventional drugs treatment has been providing effective therapy for treatment of infections caused by pathogenic microorganisms; However, some do not respond to conventional therapy. Conventional therapy are expensive and have more adverse side effects. Plant based medicinal productshas been used as an alternative curative for infections caused by resistant pathogenic microorganisms, moreover, plant medicinal products have less adverse side effects. This study was conducted to assess thecrude Combretummolle bark extracts antimicrobial activityagainst three selected bacteria species. Three solvents, distilled water; ethanol and acetone were used for crude combretum molle bark extraction. The agar well diffusion method was used to assess antimicrobial activity against Streptococcus pyogenes, Pseudomonas aeruginosa and Escherichia coli. A minimum inhibition concentration (MIC) of the most active extracts was determined by the broth dilution technique. Extracts from three solvents tested demonstrated antimicrobial activity with zone of inhibition diameters ranging from 14 to 24 mm. Acetone extract was the most potent with its minimum inhibitory concentration (MIC) ranging from 1.25 to 2.50 mg/ml. There was no statistically significant difference (P>0.05) in the potency of the three extracts and standard antibiotic ciprofloxacin on the bacteria species tested. The study showed that the crude bark extract of C. molle has antimicrobial activity against all the test microorganisms.
| Published in | International Journal of Biochemistry, Biophysics & Molecular Biology (Volume 6, Issue 2) |
| DOI | 10.11648/j.ijbbmb.20210602.14 |
| Page(s) | 52-55 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Combretum Molle Crude Bark Extract, Streptococcus Pyogenes, Pseudomonas Aeruginosa Escherichia Coli, Antimicrobial Activity
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APA Style
Mohamed Hamed Sango Ally, Frida Richard Mgonja. (2021). Assessment of Antimicrobial Activity of Velvet Bush Willow (Combretum molle) Crude Bark Extracts on Selected Bacteria Species. International Journal of Biochemistry, Biophysics & Molecular Biology, 6(2), 52-55. https://doi.org/10.11648/j.ijbbmb.20210602.14
ACS Style
Mohamed Hamed Sango Ally; Frida Richard Mgonja. Assessment of Antimicrobial Activity of Velvet Bush Willow (Combretum molle) Crude Bark Extracts on Selected Bacteria Species. Int. J. Biochem. Biophys. Mol. Biol. 2021, 6(2), 52-55. doi: 10.11648/j.ijbbmb.20210602.14
AMA Style
Mohamed Hamed Sango Ally, Frida Richard Mgonja. Assessment of Antimicrobial Activity of Velvet Bush Willow (Combretum molle) Crude Bark Extracts on Selected Bacteria Species. Int J Biochem Biophys Mol Biol. 2021;6(2):52-55. doi: 10.11648/j.ijbbmb.20210602.14
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Download@article{10.11648/j.ijbbmb.20210602.14,
author = {Mohamed Hamed Sango Ally and Frida Richard Mgonja},
title = {Assessment of Antimicrobial Activity of Velvet Bush Willow (Combretum molle) Crude Bark Extracts on Selected Bacteria Species},
journal = {International Journal of Biochemistry, Biophysics & Molecular Biology},
volume = {6},
number = {2},
pages = {52-55},
doi = {10.11648/j.ijbbmb.20210602.14},
url = {https://doi.org/10.11648/j.ijbbmb.20210602.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbbmb.20210602.14},
abstract = {Treatment and control of infectious diseases in humans and animals play a vital role in prevention of illness and death. Conventional drugs treatment has been providing effective therapy for treatment of infections caused by pathogenic microorganisms; However, some do not respond to conventional therapy. Conventional therapy are expensive and have more adverse side effects. Plant based medicinal productshas been used as an alternative curative for infections caused by resistant pathogenic microorganisms, moreover, plant medicinal products have less adverse side effects. This study was conducted to assess thecrude Combretummolle bark extracts antimicrobial activityagainst three selected bacteria species. Three solvents, distilled water; ethanol and acetone were used for crude combretum molle bark extraction. The agar well diffusion method was used to assess antimicrobial activity against Streptococcus pyogenes, Pseudomonas aeruginosa and Escherichia coli. A minimum inhibition concentration (MIC) of the most active extracts was determined by the broth dilution technique. Extracts from three solvents tested demonstrated antimicrobial activity with zone of inhibition diameters ranging from 14 to 24 mm. Acetone extract was the most potent with its minimum inhibitory concentration (MIC) ranging from 1.25 to 2.50 mg/ml. There was no statistically significant difference (P>0.05) in the potency of the three extracts and standard antibiotic ciprofloxacin on the bacteria species tested. The study showed that the crude bark extract of C. molle has antimicrobial activity against all the test microorganisms.},
year = {2021}
}
TY - JOUR T1 - Assessment of Antimicrobial Activity of Velvet Bush Willow (Combretum molle) Crude Bark Extracts on Selected Bacteria Species AU - Mohamed Hamed Sango Ally AU - Frida Richard Mgonja Y1 - 2021/10/12 PY - 2021 N1 - https://doi.org/10.11648/j.ijbbmb.20210602.14 DO - 10.11648/j.ijbbmb.20210602.14 T2 - International Journal of Biochemistry, Biophysics & Molecular Biology JF - International Journal of Biochemistry, Biophysics & Molecular Biology JO - International Journal of Biochemistry, Biophysics & Molecular Biology SP - 52 EP - 55 PB - Science Publishing Group SN - 2575-5862 UR - https://doi.org/10.11648/j.ijbbmb.20210602.14 AB - Treatment and control of infectious diseases in humans and animals play a vital role in prevention of illness and death. Conventional drugs treatment has been providing effective therapy for treatment of infections caused by pathogenic microorganisms; However, some do not respond to conventional therapy. Conventional therapy are expensive and have more adverse side effects. Plant based medicinal productshas been used as an alternative curative for infections caused by resistant pathogenic microorganisms, moreover, plant medicinal products have less adverse side effects. This study was conducted to assess thecrude Combretummolle bark extracts antimicrobial activityagainst three selected bacteria species. Three solvents, distilled water; ethanol and acetone were used for crude combretum molle bark extraction. The agar well diffusion method was used to assess antimicrobial activity against Streptococcus pyogenes, Pseudomonas aeruginosa and Escherichia coli. A minimum inhibition concentration (MIC) of the most active extracts was determined by the broth dilution technique. Extracts from three solvents tested demonstrated antimicrobial activity with zone of inhibition diameters ranging from 14 to 24 mm. Acetone extract was the most potent with its minimum inhibitory concentration (MIC) ranging from 1.25 to 2.50 mg/ml. There was no statistically significant difference (P>0.05) in the potency of the three extracts and standard antibiotic ciprofloxacin on the bacteria species tested. The study showed that the crude bark extract of C. molle has antimicrobial activity against all the test microorganisms. VL - 6 IS - 2 ER -
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