Acne is a complicated and chronic inflammatory skin disorder, frequently existed at areas with thriving lipid secretion. Among various cosmetic actives, hydroxy acids (HA) emerged as one of the most effective ingredients, and a combination of HAs could provide a synergistic effect and better therapeutic outcome to acne. However, there was no systematic analysis and prediction to explain the synergistic mechanism. The aim of this study was to undercover the overlapping gene targets of formula ingredients and skin diseases, as well as possible interconnected pathways, thus to have a deeper understanding on the function of complex formula. Network pharmacology was utilized to obtain the gene targets of each active against acne and sebum balance. Molecular function, biological process, cellular component and signaling pathway were calculated through protein-protein interaction (PPI) and enrichment analysis. Furthermore, interaction mapping among actives, biological processes and pathways were established by Cytoscape software. 283 targets of HAs-based formula against acne/sebum balance were obtained. 10 hub genes including ALB, EGFR, AKT1, MMP9, SRC, HRAS, CCL5, IL2, CAT and KDR were also achieved. The interaction between hub genes, biological processes and pathways were visualized into network mappings. All the targets contributed to the improvement of acne via sebum modulation, anti-oxidation and immune regulation. Network pharmacology acted as an effective method in exploring the multi-ingredient formula. Through the precise target and pathway analysis, this study showed that HAs-based formula could function in multiple dimensions to regulate the balance of sebum secretion and ameliorate the damage of acne.
| Published in | Biochemistry and Molecular Biology (Volume 7, Issue 2) |
| DOI | 10.11648/j.bmb.20220702.12 |
| Page(s) | 25-34 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Hydroxy Acid, Systematic Pharmacology, Acne, Sebum Balance
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APA Style
Xiaoyu Ma, Jiahong Guo, Fernando Bouffard, Nianping Feng, Sophia Yi Zhang. (2022). Therapeutic Mechanisms of α-/β-Hydroxy Acid Complex on Skin Sebum Balance and Acne via Network Pharmacology. Biochemistry and Molecular Biology, 7(2), 25-34. https://doi.org/10.11648/j.bmb.20220702.12
ACS Style
Xiaoyu Ma; Jiahong Guo; Fernando Bouffard; Nianping Feng; Sophia Yi Zhang. Therapeutic Mechanisms of α-/β-Hydroxy Acid Complex on Skin Sebum Balance and Acne via Network Pharmacology. Biochem. Mol. Biol. 2022, 7(2), 25-34. doi: 10.11648/j.bmb.20220702.12
AMA Style
Xiaoyu Ma, Jiahong Guo, Fernando Bouffard, Nianping Feng, Sophia Yi Zhang. Therapeutic Mechanisms of α-/β-Hydroxy Acid Complex on Skin Sebum Balance and Acne via Network Pharmacology. Biochem Mol Biol. 2022;7(2):25-34. doi: 10.11648/j.bmb.20220702.12
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Download@article{10.11648/j.bmb.20220702.12,
author = {Xiaoyu Ma and Jiahong Guo and Fernando Bouffard and Nianping Feng and Sophia Yi Zhang},
title = {Therapeutic Mechanisms of α-/β-Hydroxy Acid Complex on Skin Sebum Balance and Acne via Network Pharmacology},
journal = {Biochemistry and Molecular Biology},
volume = {7},
number = {2},
pages = {25-34},
doi = {10.11648/j.bmb.20220702.12},
url = {https://doi.org/10.11648/j.bmb.20220702.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20220702.12},
abstract = {Acne is a complicated and chronic inflammatory skin disorder, frequently existed at areas with thriving lipid secretion. Among various cosmetic actives, hydroxy acids (HA) emerged as one of the most effective ingredients, and a combination of HAs could provide a synergistic effect and better therapeutic outcome to acne. However, there was no systematic analysis and prediction to explain the synergistic mechanism. The aim of this study was to undercover the overlapping gene targets of formula ingredients and skin diseases, as well as possible interconnected pathways, thus to have a deeper understanding on the function of complex formula. Network pharmacology was utilized to obtain the gene targets of each active against acne and sebum balance. Molecular function, biological process, cellular component and signaling pathway were calculated through protein-protein interaction (PPI) and enrichment analysis. Furthermore, interaction mapping among actives, biological processes and pathways were established by Cytoscape software. 283 targets of HAs-based formula against acne/sebum balance were obtained. 10 hub genes including ALB, EGFR, AKT1, MMP9, SRC, HRAS, CCL5, IL2, CAT and KDR were also achieved. The interaction between hub genes, biological processes and pathways were visualized into network mappings. All the targets contributed to the improvement of acne via sebum modulation, anti-oxidation and immune regulation. Network pharmacology acted as an effective method in exploring the multi-ingredient formula. Through the precise target and pathway analysis, this study showed that HAs-based formula could function in multiple dimensions to regulate the balance of sebum secretion and ameliorate the damage of acne.},
year = {2022}
}
TY - JOUR T1 - Therapeutic Mechanisms of α-/β-Hydroxy Acid Complex on Skin Sebum Balance and Acne via Network Pharmacology AU - Xiaoyu Ma AU - Jiahong Guo AU - Fernando Bouffard AU - Nianping Feng AU - Sophia Yi Zhang Y1 - 2022/05/26 PY - 2022 N1 - https://doi.org/10.11648/j.bmb.20220702.12 DO - 10.11648/j.bmb.20220702.12 T2 - Biochemistry and Molecular Biology JF - Biochemistry and Molecular Biology JO - Biochemistry and Molecular Biology SP - 25 EP - 34 PB - Science Publishing Group SN - 2575-5048 UR - https://doi.org/10.11648/j.bmb.20220702.12 AB - Acne is a complicated and chronic inflammatory skin disorder, frequently existed at areas with thriving lipid secretion. Among various cosmetic actives, hydroxy acids (HA) emerged as one of the most effective ingredients, and a combination of HAs could provide a synergistic effect and better therapeutic outcome to acne. However, there was no systematic analysis and prediction to explain the synergistic mechanism. The aim of this study was to undercover the overlapping gene targets of formula ingredients and skin diseases, as well as possible interconnected pathways, thus to have a deeper understanding on the function of complex formula. Network pharmacology was utilized to obtain the gene targets of each active against acne and sebum balance. Molecular function, biological process, cellular component and signaling pathway were calculated through protein-protein interaction (PPI) and enrichment analysis. Furthermore, interaction mapping among actives, biological processes and pathways were established by Cytoscape software. 283 targets of HAs-based formula against acne/sebum balance were obtained. 10 hub genes including ALB, EGFR, AKT1, MMP9, SRC, HRAS, CCL5, IL2, CAT and KDR were also achieved. The interaction between hub genes, biological processes and pathways were visualized into network mappings. All the targets contributed to the improvement of acne via sebum modulation, anti-oxidation and immune regulation. Network pharmacology acted as an effective method in exploring the multi-ingredient formula. Through the precise target and pathway analysis, this study showed that HAs-based formula could function in multiple dimensions to regulate the balance of sebum secretion and ameliorate the damage of acne. VL - 7 IS - 2 ER -
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