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Effect of Cow Start Bolus Supplementation on Early Lactation Health and Performance Indicators in a Group of Older, At-Risk Dairy Cows

Received: 9 September 2021    Accepted: 24 September 2021    Published: 5 October 2021
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Abstract

Whilst older cows can be some of the most profitable producers on the farm, as well as helping to reduce the environmental impact of dairy production and improving consumer perception of dairy farming, they can also be more prone to early lactation metabolic challenges and at higher risk of culling or death in early lactation. Research into nutritional supplementation strategies specifically to support older, at-risk herd members has not, to the author’s knowledge, been carried out and leaves a dearth of knowledge as to how best to support the successful transition of this valuable cohort of cows from gestation into peak lactation. The objective of this study was to evaluate the effect of supplementation with a combined calcium, magnesium and antioxidant bolus (Cow Start) on key early lactation health and performance indicators in a cohort of older, higher yielding dairy cows that may be expected to be at greater risk of developing key post-partum metabolic disorders. High yielding multiparous (n=38) cows averaging 4.7 lactations at calving were enrolled in this study and randomly assigned to either a control (CON, n=19) group or a Cow Start oral bolus supplemented (CSC, n=19) group. The CON group experienced a clinical milk fever (Blood Ca < 1.5 mM) incidence rate of 15.7% compared to 0% for the CSC group. Cows in the CSC group recorded a treatment effect of a significantly (P < 0.01) higher blood calcium status compared to CON. Energy Corrected Milk volumes showed a statistical trend of an increase (P < 0.10) from day 5 until day 60 of lactation for the CSC group (+1.8 kg/day) when compared to CON, also milk fat kg (P < 0.05) and combined fat and protein kg yields (P < 0.10) were increased in the CSC group when compared to the CON group. Results of this study suggest that supplementation of older at-risk cows with a combined calcium, magnesium and antioxidant (Cow Start) oral bolus can reduce the incidence rate of clinical milk fever and exposure to sub-clinical milk fever, whilst also improving blood calcium status and increasing milk production parameters in early lactation when compared to CON.

Published in Animal and Veterinary Sciences (Volume 9, Issue 5)
DOI 10.11648/j.avs.20210905.12
Page(s) 134-140
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Calcium and Antioxidant Bolus, Post-Partum Calcium Status, Early Lactation At-Risk Cows

References
[1] F. Grandl, M. Furger, M. Kreuzer, and M. Zehetmeier, “Impact of longevity on greenhouse gas emissions and profitability of individual dairy cows analysed with different system boundaries”. Animal, vol. 13: 1, pp 198–208, 2019.
[2] I. Komlósi, M. Wolfová, J. Wolf, B. Farkas, Z. Szendrei, Z. and B. Béri, “Economic weights of production and functional traits for Holstein-Friesian cattle in Hungary”. J. Anim. Breed. Genet., vol. 127, 143–153, 2010.
[3] FAO, 2013. Available at http://faostat.fao.org/site/569/DesktopDefault.aspx?PageID=569#ancor
[4] A. C. Boulton, J. Rushton, and D. C. Wathes, “An empirical analysis of the cost of rearing dairy heifers from birth to first calving and the time taken to repay these costs”. Animal vol. 11, 1372–1380, 2017.
[5] D. Pellerin, S. Adams, F. Bécotte, R. Cue, R. Moore, and R. Roy, “Pour une vache, l’âge d’or c’est la 4e lactation” In In Proceedings of the Symposium sur les Bovins Laitiers: Choix D’aujourd’hui Pour les Défis de Demain, CRAAQ—Le Centre de Référence en Agriculture et Agroalimentaire du Québec, Saint-Hyacinthe, QC, Canada, 5 November 2014; pp. 133–147.
[6] H. A. Seifi, S. J. LeBlanc, K. E. Leslie and T. F. Duffield, “Metabolic predictors of postpartum disease and culling risk in dairy cattle”. The Veterinary Journal vol. 188, 216–220, 2011.
[7] J. P. Goff, ‘The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows’, The Veterinary Journal, vol. 176, no. 1, pp. 50–57, 2008, https://doi.org/10.1016/j.tvjl.2007.12.020
[8] T. A. Reinhardt, J. D. Lippolis, B. J. McCluskey, J. P. Goff, and R. L. Horst, ‘Prevalence of subclinical hypocalcemia in dairy herds,’ The Veterinary Journal, vol. 188, no. 1, pp. 122–124, 2011, https://doi.org/10.1016/j.tvjl.2010.03.025
[9] M. Probo, O. B. Pascottini, S. LeBlanc, G. Opsomer, and M. Hostens, “Association between metabolic diseases and the culling risk of high-yielding dairy cows in a transition management facility using survival and decision tree analysis,” Journal of Dairy Science vol. 101, 9419–9429, 2018.
[10] R. L. Horst, J. P. Goff, and T. A. Reinhardt, ‘Adapting to the Transition Between Gestation and Lactation: Differences Between Rat, Human and Dairy Cow’, Journal of Mammary Gland Biology and Neoplasia, vol. 10, no. 2, pp. 141–156, 2005.
[11] P. J. De Garis, I. J. Lean, ‘Milk fever in dairy cows: A review of pathophysiology and control principles’, The Veterinary Journal, vol. 176, no. 1, pp. 58 – 69, 2008, https://doi.org/10.1016/j.tvjl.2007.12.029
[12] F. Mulligan, L. O’Grady, D. Rice, and M. Doherty, ‘Production diseases of the transition cow: Milk fever and subclinical hypocalcaemia’, Irish Veterinary Journal, vol. 59, no. 12, pp. 697 – 701, 2006.
[13] N. Martinez, C. A. Risco, F. S. Lima, R. S. Bisinotto, L. F. Grego, E. S. Riberio, F. Maunsell, K. Galvao, and J. E. P. Santos. “Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease,” J. Dairy Sci. vol. 95: 7158–7172, 2012, doi: 10.3168/jds.2012-5812.
[14] R. J. Jorgenson, N. R. Nyengaard, S. Hara, J. M. Enemark and P. H. Andersen ‘Rumen motility during induced hyper- and hypocalcaemia’. Acta. Vet. Scand. Vol 39: 331-338, 1998.
[15] T. Y. Ma, D. Tran, N. Hoa, D. Nguyen, M. Merryfield and A. Tarnawski, ‘Mechanism of Extracellular Calcium Regulation of Intestinal Epithelial Tight Junction Permeability: Role of Cytoskeletal Involvement’. Microscopy Research and Technique vol 51, 156-168, 2000.
[16] K. Kimura, T. A. Reinhardt, and J. P. Goff, ‘Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle’, Journal of dairy science, vol. 89, no. 7, pp. 2588-2595, 2006, https://doi.org/10.3168/jds.S0022-0302(06)72335-9
[17] L. C. Whiteford, and I. M. Sheldon, “Association between clinical hypocalcaemia and postpartum endometritis,” The Veterinary Record vol. 157, 202-204, 2005.
[18] R. K. Rude, S. B. Oldham, C. F. Sharp Jr., and F. R. Singer, “Parathyroid Hormone Secretion in Magnesium Deficiency*,” J. Clin. Endocrinol. Metab., vol. 47, no. 4, pp. 800–806, Oct. 1978, doi: 10.1210/jcem-47-4-800.
[19] E. T. Littledike, J. A. Stuedemann, S. R. Wilkinson, and R. L. Horst, “Grass Tetany Syndrome,” in Proc. John Lee Pratt Int. Symp. Role Magnes. Anim. Nutr, Virginia Polytechnic Institute and State University, p. 173, 1983.
[20] S. J. LeBlanc, et al., ‘Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease’, J Dairy Sci, 2004. 87 (3): p. 609-19, 2004.
[21] C. K. Cebra, et al., The relationship between endogenous cortisol, blood micronutrients, and neutrophil function in postparturient Holstein cows, J Vet Intern Med, vol. 17 (6): p. 902-7, 2003.
[22] J. W. Spears, and W. P. Weiss, Role of antioxidants and trace elements in health and immunity of transition dairy cows, Vet J, 176 (1): p. 70-6, 2008.
[23] Hogan, J. S., et al., Bovine neutrophil responses to parenteral vitamin E. J Dairy Sci, 75 (2): p. 399-405, 1992.
[24] G. R. Oetzel, and B. E. Miller. 2012. “Effect of oral calcium bolus supplementation on early-lactation health and milk yield in commercial dairy herds,” J. Dairy Sci. vol. 95: 7051–7065, 2012, doi.org/10.3168/ jds.2012-5510.
[25] J. A. A. McArt, and G. R. Oetzel, “A stochastic estimate of the economic impact of oral calcium supplementation in post parturient cows,” Journal of Dairy Science vol. 98: 7408–7418, 2015, doi.org/10.3168/jds.2015-9479.
[26] A. Valldacabres, J. A. A. Pires, and N. Silva-del-Rio, “Effect of prophylactic oral calcium supplementation on postpartum mineral status and markers of energy balance of multiparous Jersey cows,” J. Dairy Sci. vol. 101: 4460–4472, 2018, doi.org/10.3168/jds.2017-12917.
[27] B. M. Leno, R. C. Neves, I. M. Louge, M. D. Curler, M. J. Thomas, T. R. Overton, and J. A. A. McArt. “Differential effects of a single dose of oral calcium based on postpartum plasma calcium concentration in Holstein cows,” J. Dairy Sci. vol. 101: 3285–3302, 2018, doi.org/10.3168/jds.2017-13164.
[28] J. Lawlor, A. Fahey, E. Neville, A. Stack, and F. Mulligan, “On-farm Safety and Efficacy Trial of Cow Start Calcium Bolus,” Anim. Vet. Sci., vol. 7, no. 6, pp. 121–126, 2019, doi: 10.11648/j.avs.20190706.11.
[29] Lawlor, J., Fahey, A., Neville, E., Stack, A., and Mulligan, F. “Effect of Cow Start Calcium Bolus on &lt;etabolic Status and Milk Production in Early Lactation,” Anim Vet Sci., vol. 8, no. 6, pp. 124-132, 2020, doi: 10.11648/j.avs.20200806.12.
[30] European Commission, Milk and Dairy Products, information on production, accessed on Aug 18th 2021, available at https://ec.europa.eu/info/sites/default/files/food-farming-fisheries/farming/documents/eu-milk-yield-herds_en.pdf
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    John Lawlor, Rachel Reardon, Cathal O’ Sé, Enda Neville, Alan Fahey. (2021). Effect of Cow Start Bolus Supplementation on Early Lactation Health and Performance Indicators in a Group of Older, At-Risk Dairy Cows. Animal and Veterinary Sciences, 9(5), 134-140. https://doi.org/10.11648/j.avs.20210905.12

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    John Lawlor; Rachel Reardon; Cathal O’ Sé; Enda Neville; Alan Fahey. Effect of Cow Start Bolus Supplementation on Early Lactation Health and Performance Indicators in a Group of Older, At-Risk Dairy Cows. Anim. Vet. Sci. 2021, 9(5), 134-140. doi: 10.11648/j.avs.20210905.12

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    AMA Style

    John Lawlor, Rachel Reardon, Cathal O’ Sé, Enda Neville, Alan Fahey. Effect of Cow Start Bolus Supplementation on Early Lactation Health and Performance Indicators in a Group of Older, At-Risk Dairy Cows. Anim Vet Sci. 2021;9(5):134-140. doi: 10.11648/j.avs.20210905.12

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  • @article{10.11648/j.avs.20210905.12,
      author = {John Lawlor and Rachel Reardon and Cathal O’ Sé and Enda Neville and Alan Fahey},
      title = {Effect of Cow Start Bolus Supplementation on Early Lactation Health and Performance Indicators in a Group of Older, At-Risk Dairy Cows},
      journal = {Animal and Veterinary Sciences},
      volume = {9},
      number = {5},
      pages = {134-140},
      doi = {10.11648/j.avs.20210905.12},
      url = {https://doi.org/10.11648/j.avs.20210905.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20210905.12},
      abstract = {Whilst older cows can be some of the most profitable producers on the farm, as well as helping to reduce the environmental impact of dairy production and improving consumer perception of dairy farming, they can also be more prone to early lactation metabolic challenges and at higher risk of culling or death in early lactation. Research into nutritional supplementation strategies specifically to support older, at-risk herd members has not, to the author’s knowledge, been carried out and leaves a dearth of knowledge as to how best to support the successful transition of this valuable cohort of cows from gestation into peak lactation. The objective of this study was to evaluate the effect of supplementation with a combined calcium, magnesium and antioxidant bolus (Cow Start) on key early lactation health and performance indicators in a cohort of older, higher yielding dairy cows that may be expected to be at greater risk of developing key post-partum metabolic disorders. High yielding multiparous (n=38) cows averaging 4.7 lactations at calving were enrolled in this study and randomly assigned to either a control (CON, n=19) group or a Cow Start oral bolus supplemented (CSC, n=19) group. The CON group experienced a clinical milk fever (Blood Ca < 1.5 mM) incidence rate of 15.7% compared to 0% for the CSC group. Cows in the CSC group recorded a treatment effect of a significantly (P < 0.01) higher blood calcium status compared to CON. Energy Corrected Milk volumes showed a statistical trend of an increase (P < 0.10) from day 5 until day 60 of lactation for the CSC group (+1.8 kg/day) when compared to CON, also milk fat kg (P < 0.05) and combined fat and protein kg yields (P < 0.10) were increased in the CSC group when compared to the CON group. Results of this study suggest that supplementation of older at-risk cows with a combined calcium, magnesium and antioxidant (Cow Start) oral bolus can reduce the incidence rate of clinical milk fever and exposure to sub-clinical milk fever, whilst also improving blood calcium status and increasing milk production parameters in early lactation when compared to CON.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Effect of Cow Start Bolus Supplementation on Early Lactation Health and Performance Indicators in a Group of Older, At-Risk Dairy Cows
    AU  - John Lawlor
    AU  - Rachel Reardon
    AU  - Cathal O’ Sé
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    T2  - Animal and Veterinary Sciences
    JF  - Animal and Veterinary Sciences
    JO  - Animal and Veterinary Sciences
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    EP  - 140
    PB  - Science Publishing Group
    SN  - 2328-5850
    UR  - https://doi.org/10.11648/j.avs.20210905.12
    AB  - Whilst older cows can be some of the most profitable producers on the farm, as well as helping to reduce the environmental impact of dairy production and improving consumer perception of dairy farming, they can also be more prone to early lactation metabolic challenges and at higher risk of culling or death in early lactation. Research into nutritional supplementation strategies specifically to support older, at-risk herd members has not, to the author’s knowledge, been carried out and leaves a dearth of knowledge as to how best to support the successful transition of this valuable cohort of cows from gestation into peak lactation. The objective of this study was to evaluate the effect of supplementation with a combined calcium, magnesium and antioxidant bolus (Cow Start) on key early lactation health and performance indicators in a cohort of older, higher yielding dairy cows that may be expected to be at greater risk of developing key post-partum metabolic disorders. High yielding multiparous (n=38) cows averaging 4.7 lactations at calving were enrolled in this study and randomly assigned to either a control (CON, n=19) group or a Cow Start oral bolus supplemented (CSC, n=19) group. The CON group experienced a clinical milk fever (Blood Ca < 1.5 mM) incidence rate of 15.7% compared to 0% for the CSC group. Cows in the CSC group recorded a treatment effect of a significantly (P < 0.01) higher blood calcium status compared to CON. Energy Corrected Milk volumes showed a statistical trend of an increase (P < 0.10) from day 5 until day 60 of lactation for the CSC group (+1.8 kg/day) when compared to CON, also milk fat kg (P < 0.05) and combined fat and protein kg yields (P < 0.10) were increased in the CSC group when compared to the CON group. Results of this study suggest that supplementation of older at-risk cows with a combined calcium, magnesium and antioxidant (Cow Start) oral bolus can reduce the incidence rate of clinical milk fever and exposure to sub-clinical milk fever, whilst also improving blood calcium status and increasing milk production parameters in early lactation when compared to CON.
    VL  - 9
    IS  - 5
    ER  - 

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Author Information
  • Anchor Life Science Ltd., Co. Cork, Ireland

  • Anchor Life Science Ltd., Co. Cork, Ireland

  • Reprovet Ltd., Co. Cork, Ireland

  • School of Agriculture and Food Science, University College Dublin, Dublin, Ireland

  • School of Agriculture and Food Science, University College Dublin, Dublin, Ireland

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