Description of the Histological Features in Wounds of Snake Bite Aetiology

Dissanayakalage Ajith Dissanayake; Cherine Susanthy Priyadharshini Sosai; Mawathagama Gedara Lional Weerawardane; Jayavickrama Withanage Sriya Priyadharshanie; Rajapakse Peramune Vedikkarage Jayanthe Rajapakse; Senanayake Abeysinghe Mudiyanselage Kularatne

doi:doi:10.11648/j.ass.20170504.15

Description of the Histological Features in Wounds of Snake Bite Aetiology

Dissanayakalage Ajith Dissanayake, Cherine Susanthy Priyadharshini Sosai, Mawathagama Gedara Lional Weerawardane, Jayavickrama Withanage Sriya Priyadharshanie, Rajapakse Peramune Vedikkarage Jayanthe Rajapakse, Senanayake Abeysinghe Mudiyanselage Kularatne

Published in Advances in Surgical Sciences (Volume 5, Issue 4)

Received: 21 February 2017 Accepted: 6 May 2017 Published: 3 August 2017

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Abstract

The chronic wounds that develop following snake bites may display a spectrum of histological features that could be correlated with the type of venom injected. The pathological changes may provide useful information for the management of chronic wounds that develop following snake bites. This study intends to assess the histopathological changes seen in chronic wounds following Daboia russelii (Russell’s viper), Hypnale species (Hump nosed viper) and Naja naja (Cobra) bites and wounds of non snake bite aetiology. Inflammatory cells were seen in snake bite and non snake bite wounds. An intense mixed cellular inflammatory cell presence around the vessels could be seen. More lymphocytes and plasma cells were seen in wounds following snake bite and presence of more eosinophils was detected in wounds with other aetiology. Haemorrhagic areas in the dermis were seen in tissue samples taken from Naja naja and Hypnale species bite wounds. Vascular proliferation was predominant in all chronic wounds following snake bite. Granulation tissues were also more in chronic wounds following snake bites than the wounds of other aetiology. Among these three snake bites, haemorrhage was present mainly in Naja naja and Hypnale bite wounds compared to Daboia russelii.

Published in	Advances in Surgical Sciences (Volume 5, Issue 4)
DOI	10.11648/j.ass.20170504.15
Page(s)	57-60
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Histopathology, Chronic Wound, Russell’s Viper, Hump Nosed Viper, Cobra, Aetiology

References

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[3]	Kularatne SAM, Ratnatunge N. Severe systemic effects of Merrem’s hump-nosed viper bite. Ceylon Medical Journal 1999; 44: 169–70.
[4]	Phillips RE, Theakston RDG, Warrell DA, Galigedara Y, Abeysekara DTDJ, Dissanayake P, et al. Paralysis, rhabdomyolysis and haemolysis caused by bites of Russell’s viper (Vipera Russelli Pulchella) in Sri Lanka: failure of Indian (Haffkine) antivenom. Quarterly Journal of Medicine, New Series 1988; 68: 691–716.
[5]	Graves, N. and Zheng, H., 2014. The prevalence and incidence of chronic wounds: a literature review. Wound Practice & Research: Journal of the Australian Wound Management Association, 22(1), p. 4.
[6]	Gottrup, F., Apelqvist, J. and Price, P., 2010. Outcomes in controlled and comparative studies on non-healing wounds: recommendations. J Wound Care, 19(6), pp. 237-268.
[7]	Leach, M. J., 2004. Making sense of the venous leg ulcer debate: a literature review. Journal of wound care, 13(2), pp. 52-56.
[8]	Sidgwick, G. P., Mc George, D. and Bayat, A., 2015. A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring. Archives of dermatological research, 307(6), pp. 461-477.
[9]	Graves, N. and Zheng, H., 2014. Modelling the direct health care costs of chronic oundsin Australia. Wound Practice & Research: Journal of the Australian Wound Management Association, 22(1), p. 20.
[10]	Kasturiratne, A., Wickremasinghe, A. R., de Silva, N., Gunawardena, N. K., Pathmeswaran, A., Premaratna, R., Savioli, L., Lalloo, D. G. and de Silva, H. J., 2008. The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths. PLoS Med, 5(11), p. e218.
[11]	Brunda, G. and Sashidhar, R. B., 2007. Epidemiological profile of snake-bite cases from Andhra Pradesh using immune analytical approach. Indian journal of medical research, 125(5), p. 661.
[12]	Nayak, B. S., Sandiford, S. and Maxwell, A., 2009. Evaluation of the wound-healing activity of ethanolic extract of Morinda citrifolia L. leaf. Evidence-Based Complementary and Alternative Medicine, 6(3), pp. 351-356.
[13]	G. Pierce, Ph. D., MD, G. F. and Mustoe, MD, T. A., 1995. Pharmacologic enhancement of wound healing. Annual review of medicine, 46(1), pp. 467-481.
[14]	Chereddy, K. K., Vandermeulen, G. and Préat, V., 2016. PLGA based drug delivery systems: Promising carriers for wound healing activity. Wound Repair and Regeneration, 24(2), pp. 223-236.
[15]	W. Welton, R. E., Williams, D. J. and Liew, D., 2016. Injury trends from envenoming in Australia, 2000‐2013. Internal medicine journal.

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Dissanayakalage Ajith Dissanayake, Cherine Susanthy Priyadharshini Sosai, Mawathagama Gedara Lional Weerawardane, Jayavickrama Withanage Sriya Priyadharshanie, Rajapakse Peramune Vedikkarage Jayanthe Rajapakse, et al. (2017). Description of the Histological Features in Wounds of Snake Bite Aetiology. Advances in Surgical Sciences, 5(4), 57-60. https://doi.org/10.11648/j.ass.20170504.15

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ACS Style

Dissanayakalage Ajith Dissanayake; Cherine Susanthy Priyadharshini Sosai; Mawathagama Gedara Lional Weerawardane; Jayavickrama Withanage Sriya Priyadharshanie; Rajapakse Peramune Vedikkarage Jayanthe Rajapakse, et al. Description of the Histological Features in Wounds of Snake Bite Aetiology. Adv. Surg. Sci. 2017, 5(4), 57-60. doi: 10.11648/j.ass.20170504.15

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AMA Style

Dissanayakalage Ajith Dissanayake, Cherine Susanthy Priyadharshini Sosai, Mawathagama Gedara Lional Weerawardane, Jayavickrama Withanage Sriya Priyadharshanie, Rajapakse Peramune Vedikkarage Jayanthe Rajapakse, et al. Description of the Histological Features in Wounds of Snake Bite Aetiology. Adv Surg Sci. 2017;5(4):57-60. doi: 10.11648/j.ass.20170504.15

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@article{10.11648/j.ass.20170504.15,
  author = {Dissanayakalage Ajith Dissanayake and Cherine Susanthy Priyadharshini Sosai and Mawathagama Gedara Lional Weerawardane and Jayavickrama Withanage Sriya Priyadharshanie and Rajapakse Peramune Vedikkarage Jayanthe Rajapakse and Senanayake Abeysinghe Mudiyanselage Kularatne},
  title = {Description of the Histological Features in Wounds of Snake Bite Aetiology},
  journal = {Advances in Surgical Sciences},
  volume = {5},
  number = {4},
  pages = {57-60},
  doi = {10.11648/j.ass.20170504.15},
  url = {https://doi.org/10.11648/j.ass.20170504.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20170504.15},
  abstract = {The chronic wounds that develop following snake bites may display a spectrum of histological features that could be correlated with the type of venom injected. The pathological changes may provide useful information for the management of chronic wounds that develop following snake bites. This study intends to assess the histopathological changes seen in chronic wounds following Daboia russelii (Russell’s viper), Hypnale species (Hump nosed viper) and Naja naja (Cobra) bites and wounds of non snake bite aetiology. Inflammatory cells were seen in snake bite and non snake bite wounds. An intense mixed cellular inflammatory cell presence around the vessels could be seen. More lymphocytes and plasma cells were seen in wounds following snake bite and presence of more eosinophils was detected in wounds with other aetiology. Haemorrhagic areas in the dermis were seen in tissue samples taken from Naja naja and Hypnale species bite wounds. Vascular proliferation was predominant in all chronic wounds following snake bite. Granulation tissues were also more in chronic wounds following snake bites than the wounds of other aetiology. Among these three snake bites, haemorrhage was present mainly in Naja naja and Hypnale bite wounds compared to Daboia russelii.},
 year = {2017}
}

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TY  - JOUR
T1  - Description of the Histological Features in Wounds of Snake Bite Aetiology
AU  - Dissanayakalage Ajith Dissanayake
AU  - Cherine Susanthy Priyadharshini Sosai
AU  - Mawathagama Gedara Lional Weerawardane
AU  - Jayavickrama Withanage Sriya Priyadharshanie
AU  - Rajapakse Peramune Vedikkarage Jayanthe Rajapakse
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Y1  - 2017/08/03
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DO  - 10.11648/j.ass.20170504.15
T2  - Advances in Surgical Sciences
JF  - Advances in Surgical Sciences
JO  - Advances in Surgical Sciences
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PB  - Science Publishing Group
SN  - 2376-6182
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AB  - The chronic wounds that develop following snake bites may display a spectrum of histological features that could be correlated with the type of venom injected. The pathological changes may provide useful information for the management of chronic wounds that develop following snake bites. This study intends to assess the histopathological changes seen in chronic wounds following Daboia russelii (Russell’s viper), Hypnale species (Hump nosed viper) and Naja naja (Cobra) bites and wounds of non snake bite aetiology. Inflammatory cells were seen in snake bite and non snake bite wounds. An intense mixed cellular inflammatory cell presence around the vessels could be seen. More lymphocytes and plasma cells were seen in wounds following snake bite and presence of more eosinophils was detected in wounds with other aetiology. Haemorrhagic areas in the dermis were seen in tissue samples taken from Naja naja and Hypnale species bite wounds. Vascular proliferation was predominant in all chronic wounds following snake bite. Granulation tissues were also more in chronic wounds following snake bites than the wounds of other aetiology. Among these three snake bites, haemorrhage was present mainly in Naja naja and Hypnale bite wounds compared to Daboia russelii.
VL  - 5
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Author Information

Dissanayakalage Ajith Dissanayake

Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka
Cherine Susanthy Priyadharshini Sosai

Department of Pathology, District General Hospital, Gampaha, Sri Lanka
Mawathagama Gedara Lional Weerawardane

District General Hospital, Gampaha, Sri Lanka
Jayavickrama Withanage Sriya Priyadharshanie

District General Hospital, Gampaha, Sri Lanka
Rajapakse Peramune Vedikkarage Jayanthe Rajapakse

Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka
Senanayake Abeysinghe Mudiyanselage Kularatne

Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka

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Dissanayakalage Ajith Dissanayake, Cherine Susanthy Priyadharshini Sosai, Mawathagama Gedara Lional Weerawardane, Jayavickrama Withanage Sriya Priyadharshanie, Rajapakse Peramune Vedikkarage Jayanthe Rajapakse, et al. (2017). Description of the Histological Features in Wounds of Snake Bite Aetiology. Advances in Surgical Sciences, 5(4), 57-60. https://doi.org/10.11648/j.ass.20170504.15

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ACS Style

Dissanayakalage Ajith Dissanayake; Cherine Susanthy Priyadharshini Sosai; Mawathagama Gedara Lional Weerawardane; Jayavickrama Withanage Sriya Priyadharshanie; Rajapakse Peramune Vedikkarage Jayanthe Rajapakse, et al. Description of the Histological Features in Wounds of Snake Bite Aetiology. Adv. Surg. Sci. 2017, 5(4), 57-60. doi: 10.11648/j.ass.20170504.15

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AMA Style

Dissanayakalage Ajith Dissanayake, Cherine Susanthy Priyadharshini Sosai, Mawathagama Gedara Lional Weerawardane, Jayavickrama Withanage Sriya Priyadharshanie, Rajapakse Peramune Vedikkarage Jayanthe Rajapakse, et al. Description of the Histological Features in Wounds of Snake Bite Aetiology. Adv Surg Sci. 2017;5(4):57-60. doi: 10.11648/j.ass.20170504.15

Copy | Download

@article{10.11648/j.ass.20170504.15,
  author = {Dissanayakalage Ajith Dissanayake and Cherine Susanthy Priyadharshini Sosai and Mawathagama Gedara Lional Weerawardane and Jayavickrama Withanage Sriya Priyadharshanie and Rajapakse Peramune Vedikkarage Jayanthe Rajapakse and Senanayake Abeysinghe Mudiyanselage Kularatne},
  title = {Description of the Histological Features in Wounds of Snake Bite Aetiology},
  journal = {Advances in Surgical Sciences},
  volume = {5},
  number = {4},
  pages = {57-60},
  doi = {10.11648/j.ass.20170504.15},
  url = {https://doi.org/10.11648/j.ass.20170504.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ass.20170504.15},
  abstract = {The chronic wounds that develop following snake bites may display a spectrum of histological features that could be correlated with the type of venom injected. The pathological changes may provide useful information for the management of chronic wounds that develop following snake bites. This study intends to assess the histopathological changes seen in chronic wounds following Daboia russelii (Russell’s viper), Hypnale species (Hump nosed viper) and Naja naja (Cobra) bites and wounds of non snake bite aetiology. Inflammatory cells were seen in snake bite and non snake bite wounds. An intense mixed cellular inflammatory cell presence around the vessels could be seen. More lymphocytes and plasma cells were seen in wounds following snake bite and presence of more eosinophils was detected in wounds with other aetiology. Haemorrhagic areas in the dermis were seen in tissue samples taken from Naja naja and Hypnale species bite wounds. Vascular proliferation was predominant in all chronic wounds following snake bite. Granulation tissues were also more in chronic wounds following snake bites than the wounds of other aetiology. Among these three snake bites, haemorrhage was present mainly in Naja naja and Hypnale bite wounds compared to Daboia russelii.},
 year = {2017}
}

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TY  - JOUR
T1  - Description of the Histological Features in Wounds of Snake Bite Aetiology
AU  - Dissanayakalage Ajith Dissanayake
AU  - Cherine Susanthy Priyadharshini Sosai
AU  - Mawathagama Gedara Lional Weerawardane
AU  - Jayavickrama Withanage Sriya Priyadharshanie
AU  - Rajapakse Peramune Vedikkarage Jayanthe Rajapakse
AU  - Senanayake Abeysinghe Mudiyanselage Kularatne
Y1  - 2017/08/03
PY  - 2017
N1  - https://doi.org/10.11648/j.ass.20170504.15
DO  - 10.11648/j.ass.20170504.15
T2  - Advances in Surgical Sciences
JF  - Advances in Surgical Sciences
JO  - Advances in Surgical Sciences
SP  - 57
EP  - 60
PB  - Science Publishing Group
SN  - 2376-6182
UR  - https://doi.org/10.11648/j.ass.20170504.15
AB  - The chronic wounds that develop following snake bites may display a spectrum of histological features that could be correlated with the type of venom injected. The pathological changes may provide useful information for the management of chronic wounds that develop following snake bites. This study intends to assess the histopathological changes seen in chronic wounds following Daboia russelii (Russell’s viper), Hypnale species (Hump nosed viper) and Naja naja (Cobra) bites and wounds of non snake bite aetiology. Inflammatory cells were seen in snake bite and non snake bite wounds. An intense mixed cellular inflammatory cell presence around the vessels could be seen. More lymphocytes and plasma cells were seen in wounds following snake bite and presence of more eosinophils was detected in wounds with other aetiology. Haemorrhagic areas in the dermis were seen in tissue samples taken from Naja naja and Hypnale species bite wounds. Vascular proliferation was predominant in all chronic wounds following snake bite. Granulation tissues were also more in chronic wounds following snake bites than the wounds of other aetiology. Among these three snake bites, haemorrhage was present mainly in Naja naja and Hypnale bite wounds compared to Daboia russelii.
VL  - 5
IS  - 4
ER  -

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