Bipolar mood disorder (BD) is a severe debilitating mental disorder, and a number of patients are resistant to standard treatment. We report two clinical cases of treatment resistant mania (TRM) responsive to clozapine. Mrs. A and Mrs. B are two BD patients aged 30-year-old and 34-year-old respectively. They had a similar age of BD onset at 16 years old. They both had five manic episodes at least before they had the TRM. Mrs. A had a history of allergy to haloperidol. She presented a manic episode that was unresponsive to olanzapine 20 mg daily, risperidone 4 mg daily and lithium 1,250 mg daily. Mrs. B had a history of a mania non-responsive to the association of lithium and olanzapine 20 mg daily and a history of severe depression under lithium and haloperidol 30 mg daily. She presented a manic episode resisting the association of lithium 1000 mg daily, carbamazepine 600 mg daily, quetiapine 100 mg daily and chlorpromazine 150 mg daily. They both eventually received clozapine uptitrated gradually to 300 mg daily with lithium (1,000-1,250 mg daily) with satisfactory clinical response within three weeks of starting clozapine. Clozapine seems to be efficacious in TRM. Further randomized clinical trials are needed to strengthen its evidence based indication in TRM.
| Published in | American Journal of Psychiatry and Neuroscience (Volume 9, Issue 3) |
| DOI | 10.11648/j.ajpn.20210903.15 |
| Page(s) | 107-109 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Bipolar Disorder, Antipsychotic, Treatment, Effectiveness
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APA Style
Mohamed Habib Aoun, Rabaa Jomli, Hend Jemli, Dorsaf Habbachi, Yosra Zgueb, et al. (2021). Clozapine as an Effective Antipsychotic in Treatment Resistant Mania: Two Case Reports. American Journal of Psychiatry and Neuroscience, 9(3), 107-109. https://doi.org/10.11648/j.ajpn.20210903.15
ACS Style
Mohamed Habib Aoun; Rabaa Jomli; Hend Jemli; Dorsaf Habbachi; Yosra Zgueb, et al. Clozapine as an Effective Antipsychotic in Treatment Resistant Mania: Two Case Reports. Am. J. Psychiatry Neurosci. 2021, 9(3), 107-109. doi: 10.11648/j.ajpn.20210903.15
AMA Style
Mohamed Habib Aoun, Rabaa Jomli, Hend Jemli, Dorsaf Habbachi, Yosra Zgueb, et al. Clozapine as an Effective Antipsychotic in Treatment Resistant Mania: Two Case Reports. Am J Psychiatry Neurosci. 2021;9(3):107-109. doi: 10.11648/j.ajpn.20210903.15
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Download@article{10.11648/j.ajpn.20210903.15,
author = {Mohamed Habib Aoun and Rabaa Jomli and Hend Jemli and Dorsaf Habbachi and Yosra Zgueb and Uta Ouali},
title = {Clozapine as an Effective Antipsychotic in Treatment Resistant Mania: Two Case Reports},
journal = {American Journal of Psychiatry and Neuroscience},
volume = {9},
number = {3},
pages = {107-109},
doi = {10.11648/j.ajpn.20210903.15},
url = {https://doi.org/10.11648/j.ajpn.20210903.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20210903.15},
abstract = {Bipolar mood disorder (BD) is a severe debilitating mental disorder, and a number of patients are resistant to standard treatment. We report two clinical cases of treatment resistant mania (TRM) responsive to clozapine. Mrs. A and Mrs. B are two BD patients aged 30-year-old and 34-year-old respectively. They had a similar age of BD onset at 16 years old. They both had five manic episodes at least before they had the TRM. Mrs. A had a history of allergy to haloperidol. She presented a manic episode that was unresponsive to olanzapine 20 mg daily, risperidone 4 mg daily and lithium 1,250 mg daily. Mrs. B had a history of a mania non-responsive to the association of lithium and olanzapine 20 mg daily and a history of severe depression under lithium and haloperidol 30 mg daily. She presented a manic episode resisting the association of lithium 1000 mg daily, carbamazepine 600 mg daily, quetiapine 100 mg daily and chlorpromazine 150 mg daily. They both eventually received clozapine uptitrated gradually to 300 mg daily with lithium (1,000-1,250 mg daily) with satisfactory clinical response within three weeks of starting clozapine. Clozapine seems to be efficacious in TRM. Further randomized clinical trials are needed to strengthen its evidence based indication in TRM.},
year = {2021}
}
TY - JOUR T1 - Clozapine as an Effective Antipsychotic in Treatment Resistant Mania: Two Case Reports AU - Mohamed Habib Aoun AU - Rabaa Jomli AU - Hend Jemli AU - Dorsaf Habbachi AU - Yosra Zgueb AU - Uta Ouali Y1 - 2021/08/07 PY - 2021 N1 - https://doi.org/10.11648/j.ajpn.20210903.15 DO - 10.11648/j.ajpn.20210903.15 T2 - American Journal of Psychiatry and Neuroscience JF - American Journal of Psychiatry and Neuroscience JO - American Journal of Psychiatry and Neuroscience SP - 107 EP - 109 PB - Science Publishing Group SN - 2330-426X UR - https://doi.org/10.11648/j.ajpn.20210903.15 AB - Bipolar mood disorder (BD) is a severe debilitating mental disorder, and a number of patients are resistant to standard treatment. We report two clinical cases of treatment resistant mania (TRM) responsive to clozapine. Mrs. A and Mrs. B are two BD patients aged 30-year-old and 34-year-old respectively. They had a similar age of BD onset at 16 years old. They both had five manic episodes at least before they had the TRM. Mrs. A had a history of allergy to haloperidol. She presented a manic episode that was unresponsive to olanzapine 20 mg daily, risperidone 4 mg daily and lithium 1,250 mg daily. Mrs. B had a history of a mania non-responsive to the association of lithium and olanzapine 20 mg daily and a history of severe depression under lithium and haloperidol 30 mg daily. She presented a manic episode resisting the association of lithium 1000 mg daily, carbamazepine 600 mg daily, quetiapine 100 mg daily and chlorpromazine 150 mg daily. They both eventually received clozapine uptitrated gradually to 300 mg daily with lithium (1,000-1,250 mg daily) with satisfactory clinical response within three weeks of starting clozapine. Clozapine seems to be efficacious in TRM. Further randomized clinical trials are needed to strengthen its evidence based indication in TRM. VL - 9 IS - 3 ER -
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