Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat

Touzani Asmae; Tahri Joutei Abderrafie; Khaliss Hajar; Dami Abdellah; Balouch Lhousaine; Kriouile Yamna; Zineb Imane; Gaouzi Ahmed

doi:doi:10.11648/j.ajbls.20210905.15

Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat

Touzani Asmae, Tahri Joutei Abderrafie, Khaliss Hajar, Dami Abdellah, Balouch Lhousaine, Kriouile Yamna, Zineb Imane, Gaouzi Ahmed

Published in American Journal of Biomedical and Life Sciences (Volume 9, Issue 5)

Received: 13 September 2021 Accepted: 4 October 2021 Published: 19 October 2021

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Abstract

Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that varied from -2DS to -5DS (mean: -2.5DS). Results: Analysis of the data showed a frequency of 13.5% of patients with severe growth retardation, 35% of whom had a growth hormone deficiency. The hormonal assessment showed a GH deficiency in 43% of patients with a greater difference in chronological age and bone age (2.5 years) than in non-deficient patients (2 years). Among them, 51% of patients have an elevated TSH. Magnetic resonance imaging performed in 37 cases was in favor of a pituitary anomaly in 12% of cases, including interruption of the pituitary stem (4% of cases), hypoplasia (3% of cases), an adenoma (1% of cases) and an empty sella turcica in 4% of cases. Conclusion: Severe central growth retardation is common. Systematic monitoring and follow-up of growth is essential in children, as is vaccination, in order to identify and manage early any causal pathology that may disrupt the child's growth.

Published in	American Journal of Biomedical and Life Sciences (Volume 9, Issue 5)
DOI	10.11648/j.ajbls.20210905.15
Page(s)	254-258
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Growth, Delay, Ethiologies, Stature-Weight, Children

References

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[7]	Papadimitriou A, Douros K, Papadimitriou DT, Kleanthous K, Karapanou O, Fretzayas A. (2012). Characteristics of the short Children referred to an academic pediatric endocrine clinic in Greece. J Paediatr Child Health, 48: 263-7.
[8]	Ahmid M Perry CG, Ahmed SF, Shaikh MG. (2016). Growth hormone deficiency during young adulthood and the benefits of growth hormone replacement. Endocr Connect, 5: R1-11.
[9]	Mazouzi H, Elguendaoui S, Chadli A, Elghomari H, Farouqi A. (2006). Les étiologies du retard de croissance expérience du service d’endocrinologie et maladie métabolique du CHU Ibn Rochd de Casablanca. Annales d’Endocrinologie, 67: 440.
[10]	Salhi H , Lahlou A, Dante ML , El OuahabiH , Boujraf S , Ajdi F. (2018). Stature–weight growth delays: Clinical and etiological aspects. Journal of Family Medicine and Primary Care Volume 7: Issue 5: 963-966.
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[15]	Synthesis of guiding principles on agriculture programming for nutrition. (2013). Final Draft. Rome: Food and Agriculture organization; (http://www.fao.org/fileadmin/user_upload/wa_workshop/doc s/Synthesis_of_Ag-utr_Guidance_FAO_IssuePaper_Draft.pdf.
[16]	UNICEF, Improving child nutrition: an imperative and achievable goal for global progress, New York, UNICEF, 2013. (http://www.unicef.org/french/publications/files/French_UNICEF- NutritionReport_low_res_30May2013.pdf.
[17]	Anastasios Papadimitriou, Konstantinos Douros, Dimitrios Papadimitriou, Kleanthis Kleanthous, Olga Karapanou, Andreas Fretzayas. Characteristics of the short children referred to an academic pediatric endocrine clinic in Greece. J Paediatr Child Health. 2012; 48 (3): 263-7.
[18]	Nora soumya Fedala. Ali El Mahdi Haddam b, Akila Zenati c, Farida Chentli a. (2009). Le déficit en hormone de croissance chez l’enfant : formes cliniques et biologiques Revue francophone des laboratoires, 411: 63-70.
[19]	Hanidoune. ML. (2014). Thèse de spécialité en Médecine : le retard statural chez l’enfant (à propos de 88 cas). Faculté de médecine et Pharmacie de Rabat.
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APA Style

Touzani Asmae, Tahri Joutei Abderrafie, Khaliss Hajar, Dami Abdellah, Balouch Lhousaine, et al. (2021). Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat. American Journal of Biomedical and Life Sciences, 9(5), 254-258. https://doi.org/10.11648/j.ajbls.20210905.15

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ACS Style

Touzani Asmae; Tahri Joutei Abderrafie; Khaliss Hajar; Dami Abdellah; Balouch Lhousaine, et al. Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat. Am. J. Biomed. Life Sci. 2021, 9(5), 254-258. doi: 10.11648/j.ajbls.20210905.15

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AMA Style

Touzani Asmae, Tahri Joutei Abderrafie, Khaliss Hajar, Dami Abdellah, Balouch Lhousaine, et al. Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat. Am J Biomed Life Sci. 2021;9(5):254-258. doi: 10.11648/j.ajbls.20210905.15

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@article{10.11648/j.ajbls.20210905.15,
  author = {Touzani Asmae and Tahri Joutei Abderrafie and Khaliss Hajar and Dami Abdellah and Balouch Lhousaine and Kriouile Yamna and Zineb Imane and Gaouzi Ahmed},
  title = {Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {9},
  number = {5},
  pages = {254-258},
  doi = {10.11648/j.ajbls.20210905.15},
  url = {https://doi.org/10.11648/j.ajbls.20210905.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210905.15},
  abstract = {Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that varied from -2DS to -5DS (mean: -2.5DS). Results: Analysis of the data showed a frequency of 13.5% of patients with severe growth retardation, 35% of whom had a growth hormone deficiency. The hormonal assessment showed a GH deficiency in 43% of patients with a greater difference in chronological age and bone age (2.5 years) than in non-deficient patients (2 years). Among them, 51% of patients have an elevated TSH. Magnetic resonance imaging performed in 37 cases was in favor of a pituitary anomaly in 12% of cases, including interruption of the pituitary stem (4% of cases), hypoplasia (3% of cases), an adenoma (1% of cases) and an empty sella turcica in 4% of cases. Conclusion: Severe central growth retardation is common. Systematic monitoring and follow-up of growth is essential in children, as is vaccination, in order to identify and manage early any causal pathology that may disrupt the child's growth.},
 year = {2021}
}

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TY  - JOUR
T1  - Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat
AU  - Touzani Asmae
AU  - Tahri Joutei Abderrafie
AU  - Khaliss Hajar
AU  - Dami Abdellah
AU  - Balouch Lhousaine
AU  - Kriouile Yamna
AU  - Zineb Imane
AU  - Gaouzi Ahmed
Y1  - 2021/10/19
PY  - 2021
N1  - https://doi.org/10.11648/j.ajbls.20210905.15
DO  - 10.11648/j.ajbls.20210905.15
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 254
EP  - 258
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20210905.15
AB  - Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that varied from -2DS to -5DS (mean: -2.5DS). Results: Analysis of the data showed a frequency of 13.5% of patients with severe growth retardation, 35% of whom had a growth hormone deficiency. The hormonal assessment showed a GH deficiency in 43% of patients with a greater difference in chronological age and bone age (2.5 years) than in non-deficient patients (2 years). Among them, 51% of patients have an elevated TSH. Magnetic resonance imaging performed in 37 cases was in favor of a pituitary anomaly in 12% of cases, including interruption of the pituitary stem (4% of cases), hypoplasia (3% of cases), an adenoma (1% of cases) and an empty sella turcica in 4% of cases. Conclusion: Severe central growth retardation is common. Systematic monitoring and follow-up of growth is essential in children, as is vaccination, in order to identify and manage early any causal pathology that may disrupt the child's growth.
VL  - 9
IS  - 5
ER  -

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Author Information

Touzani Asmae

Endocrinology-Diabetology-Neurology-II-CHIS-Children’s Hospital-Rabat, Faculty of Medicine and Pharmacy, University of Rabat, Rabat, Morocco
Tahri Joutei Abderrafie

Department of Biology, University Mohamed V Faculty of Sciences, Rabat, Morocco
Khaliss Hajar

Department of Biology, University Mohamed V Faculty of Sciences, Rabat, Morocco
Dami Abdellah

Laboratory, Biochemistry and Molecular Biology, University Mohamed V, Faculty of Medicine and Pharmacy, Rabat, Morocco
Balouch Lhousaine

Laboratory, Biochemistry and Molecular Biology, University Mohamed V, Faculty of Medicine and Pharmacy, Rabat, Morocco
Kriouile Yamna

Endocrinology-Diabetology-Neurology-II-CHIS-Children’s Hospital-Rabat, Faculty of Medicine and Pharmacy, University of Rabat, Rabat, Morocco
Zineb Imane

Endocrinology-Diabetology-Neurology-II-CHIS-Children’s Hospital-Rabat, Faculty of Medicine and Pharmacy, University of Rabat, Rabat, Morocco
Gaouzi Ahmed

Endocrinology-Diabetology-Neurology-II-CHIS-Children’s Hospital-Rabat, Faculty of Medicine and Pharmacy, University of Rabat, Rabat, Morocco

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APA Style

Touzani Asmae, Tahri Joutei Abderrafie, Khaliss Hajar, Dami Abdellah, Balouch Lhousaine, et al. (2021). Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat. American Journal of Biomedical and Life Sciences, 9(5), 254-258. https://doi.org/10.11648/j.ajbls.20210905.15

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ACS Style

Touzani Asmae; Tahri Joutei Abderrafie; Khaliss Hajar; Dami Abdellah; Balouch Lhousaine, et al. Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat. Am. J. Biomed. Life Sci. 2021, 9(5), 254-258. doi: 10.11648/j.ajbls.20210905.15

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AMA Style

Touzani Asmae, Tahri Joutei Abderrafie, Khaliss Hajar, Dami Abdellah, Balouch Lhousaine, et al. Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat. Am J Biomed Life Sci. 2021;9(5):254-258. doi: 10.11648/j.ajbls.20210905.15

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@article{10.11648/j.ajbls.20210905.15,
  author = {Touzani Asmae and Tahri Joutei Abderrafie and Khaliss Hajar and Dami Abdellah and Balouch Lhousaine and Kriouile Yamna and Zineb Imane and Gaouzi Ahmed},
  title = {Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {9},
  number = {5},
  pages = {254-258},
  doi = {10.11648/j.ajbls.20210905.15},
  url = {https://doi.org/10.11648/j.ajbls.20210905.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210905.15},
  abstract = {Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that varied from -2DS to -5DS (mean: -2.5DS). Results: Analysis of the data showed a frequency of 13.5% of patients with severe growth retardation, 35% of whom had a growth hormone deficiency. The hormonal assessment showed a GH deficiency in 43% of patients with a greater difference in chronological age and bone age (2.5 years) than in non-deficient patients (2 years). Among them, 51% of patients have an elevated TSH. Magnetic resonance imaging performed in 37 cases was in favor of a pituitary anomaly in 12% of cases, including interruption of the pituitary stem (4% of cases), hypoplasia (3% of cases), an adenoma (1% of cases) and an empty sella turcica in 4% of cases. Conclusion: Severe central growth retardation is common. Systematic monitoring and follow-up of growth is essential in children, as is vaccination, in order to identify and manage early any causal pathology that may disrupt the child's growth.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat
AU  - Touzani Asmae
AU  - Tahri Joutei Abderrafie
AU  - Khaliss Hajar
AU  - Dami Abdellah
AU  - Balouch Lhousaine
AU  - Kriouile Yamna
AU  - Zineb Imane
AU  - Gaouzi Ahmed
Y1  - 2021/10/19
PY  - 2021
N1  - https://doi.org/10.11648/j.ajbls.20210905.15
DO  - 10.11648/j.ajbls.20210905.15
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 254
EP  - 258
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20210905.15
AB  - Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that varied from -2DS to -5DS (mean: -2.5DS). Results: Analysis of the data showed a frequency of 13.5% of patients with severe growth retardation, 35% of whom had a growth hormone deficiency. The hormonal assessment showed a GH deficiency in 43% of patients with a greater difference in chronological age and bone age (2.5 years) than in non-deficient patients (2 years). Among them, 51% of patients have an elevated TSH. Magnetic resonance imaging performed in 37 cases was in favor of a pituitary anomaly in 12% of cases, including interruption of the pituitary stem (4% of cases), hypoplasia (3% of cases), an adenoma (1% of cases) and an empty sella turcica in 4% of cases. Conclusion: Severe central growth retardation is common. Systematic monitoring and follow-up of growth is essential in children, as is vaccination, in order to identify and manage early any causal pathology that may disrupt the child's growth.
VL  - 9
IS  - 5
ER  -

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