Esophageal cancer is one of the cancers that seriously threaten the lives and health of patients around the world. Squamous cell carcinoma accounts for a higher proportion of esophageal cancer cases. At the same time, the number of esophageal squamous cell carcinoma (ESCC) patients also has an increasing trend year by year. Therefore, it is important to identify the prognostic factors of ESCC to improve the survival and prognosis of patients. As an important sociodemographic factor, gender has an important influence on the occurrence, development and prognosis of certain diseases. However, it has not been clear from existing studies whether gender affects the prognosis of ESCC patients. The aim of this study was to determine the effect of sex on overall survival (OS) in patients with ESCC. Methods: This study analyzed 6890 patients with ESCC diagnosed from 2007 to 2015 who were identified in the SEER (Surveillance, Epidemiology, and End Results) database. Kaplan-Meier method and Cox Proportional Hazards model were used to conduct survival analysis and regression analysis to evaluate the association between gender and OS. Results: We found that the OS differed with sex in patients with ESCC, with the 5-year OS rate being higher in females (19.2%) than in males (12.9%). A Cox multivariate analysis showed that sex was an independent prognostic factor for ESCC, with the OS being significantly better in female patients than in male patients (P<0.001). Subgroup analyses showed that sex affected the survival rate of patients with American Joint Committee on Cancer tumor, node, and metastasis stages I (P=0.013), II (P<0.001), III (P=0.014), and IV (P<0.001). Conclusion: Our results suggest that the OS of patients with ESCC is significantly better in females than males. Therefore, more attention should be paid to the prognosis of male patients with ESCC, with prospective interventions and health education applied in order to improve their survival outcomes.
| Published in | American Journal of Biomedical and Life Sciences (Volume 9, Issue 1) |
| DOI | 10.11648/j.ajbls.20210901.16 |
| Page(s) | 43-52 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Sex, Esophageal Squamous Cell Carcinoma, Survival, Prognosis, Database
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APA Style
Yaoxia Li, Na Wang, Zhuorui Zhao, Jiale Wang, Jun Lyu, et al. (2021). Sex Is Related to Overall Survival in Patients with Esophageal Squamous Cell Carcinoma: A Population-Based Study. American Journal of Biomedical and Life Sciences, 9(1), 43-52. https://doi.org/10.11648/j.ajbls.20210901.16
ACS Style
Yaoxia Li; Na Wang; Zhuorui Zhao; Jiale Wang; Jun Lyu, et al. Sex Is Related to Overall Survival in Patients with Esophageal Squamous Cell Carcinoma: A Population-Based Study. Am. J. Biomed. Life Sci. 2021, 9(1), 43-52. doi: 10.11648/j.ajbls.20210901.16
AMA Style
Yaoxia Li, Na Wang, Zhuorui Zhao, Jiale Wang, Jun Lyu, et al. Sex Is Related to Overall Survival in Patients with Esophageal Squamous Cell Carcinoma: A Population-Based Study. Am J Biomed Life Sci. 2021;9(1):43-52. doi: 10.11648/j.ajbls.20210901.16
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Download@article{10.11648/j.ajbls.20210901.16,
author = {Yaoxia Li and Na Wang and Zhuorui Zhao and Jiale Wang and Jun Lyu and Qinyang Wu and Qiqi Ke and Qiaohong Yang},
title = {Sex Is Related to Overall Survival in Patients with Esophageal Squamous Cell Carcinoma: A Population-Based Study},
journal = {American Journal of Biomedical and Life Sciences},
volume = {9},
number = {1},
pages = {43-52},
doi = {10.11648/j.ajbls.20210901.16},
url = {https://doi.org/10.11648/j.ajbls.20210901.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210901.16},
abstract = {Esophageal cancer is one of the cancers that seriously threaten the lives and health of patients around the world. Squamous cell carcinoma accounts for a higher proportion of esophageal cancer cases. At the same time, the number of esophageal squamous cell carcinoma (ESCC) patients also has an increasing trend year by year. Therefore, it is important to identify the prognostic factors of ESCC to improve the survival and prognosis of patients. As an important sociodemographic factor, gender has an important influence on the occurrence, development and prognosis of certain diseases. However, it has not been clear from existing studies whether gender affects the prognosis of ESCC patients. The aim of this study was to determine the effect of sex on overall survival (OS) in patients with ESCC. Methods: This study analyzed 6890 patients with ESCC diagnosed from 2007 to 2015 who were identified in the SEER (Surveillance, Epidemiology, and End Results) database. Kaplan-Meier method and Cox Proportional Hazards model were used to conduct survival analysis and regression analysis to evaluate the association between gender and OS. Results: We found that the OS differed with sex in patients with ESCC, with the 5-year OS rate being higher in females (19.2%) than in males (12.9%). A Cox multivariate analysis showed that sex was an independent prognostic factor for ESCC, with the OS being significantly better in female patients than in male patients (PP=0.013), II (PP=0.014), and IV (P<0.001). Conclusion: Our results suggest that the OS of patients with ESCC is significantly better in females than males. Therefore, more attention should be paid to the prognosis of male patients with ESCC, with prospective interventions and health education applied in order to improve their survival outcomes.},
year = {2021}
}
TY - JOUR T1 - Sex Is Related to Overall Survival in Patients with Esophageal Squamous Cell Carcinoma: A Population-Based Study AU - Yaoxia Li AU - Na Wang AU - Zhuorui Zhao AU - Jiale Wang AU - Jun Lyu AU - Qinyang Wu AU - Qiqi Ke AU - Qiaohong Yang Y1 - 2021/01/25 PY - 2021 N1 - https://doi.org/10.11648/j.ajbls.20210901.16 DO - 10.11648/j.ajbls.20210901.16 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 43 EP - 52 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20210901.16 AB - Esophageal cancer is one of the cancers that seriously threaten the lives and health of patients around the world. Squamous cell carcinoma accounts for a higher proportion of esophageal cancer cases. At the same time, the number of esophageal squamous cell carcinoma (ESCC) patients also has an increasing trend year by year. Therefore, it is important to identify the prognostic factors of ESCC to improve the survival and prognosis of patients. As an important sociodemographic factor, gender has an important influence on the occurrence, development and prognosis of certain diseases. However, it has not been clear from existing studies whether gender affects the prognosis of ESCC patients. The aim of this study was to determine the effect of sex on overall survival (OS) in patients with ESCC. Methods: This study analyzed 6890 patients with ESCC diagnosed from 2007 to 2015 who were identified in the SEER (Surveillance, Epidemiology, and End Results) database. Kaplan-Meier method and Cox Proportional Hazards model were used to conduct survival analysis and regression analysis to evaluate the association between gender and OS. Results: We found that the OS differed with sex in patients with ESCC, with the 5-year OS rate being higher in females (19.2%) than in males (12.9%). A Cox multivariate analysis showed that sex was an independent prognostic factor for ESCC, with the OS being significantly better in female patients than in male patients (PP=0.013), II (PP=0.014), and IV (P<0.001). Conclusion: Our results suggest that the OS of patients with ESCC is significantly better in females than males. Therefore, more attention should be paid to the prognosis of male patients with ESCC, with prospective interventions and health education applied in order to improve their survival outcomes. VL - 9 IS - 1 ER -
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