Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status

Li Hongyan; Ma Jinqun; Wang Cuicui; Liu Jianfeng; Chen Yunxia; Liu Chunyan; Hou Zhenjiang

doi:doi:10.11648/j.ajbls.20210901.12

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Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status

Li Hongyan, Ma Jinqun, Wang Cuicui, Liu Jianfeng, Chen Yunxia, Liu Chunyan, Hou Zhenjiang

Published in American Journal of Biomedical and Life Sciences (Volume 9, Issue 1)

Received: 28 November 2020 Accepted: Published: 18 January 2021

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Abstract

Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (P<0.05), while the urinary iodine level of HT-B group was negatively correlated with the serum FT3 and TT4 (P<0.05), and positively correlated with TSH (P<0.05). Along with the progression of HT disease, the levels of serum TPOAb and TGAb increased successively, and there were significant differences among each group (P<0.01). The serum TSH level of high TPOAb group and high TgAb group were respectively higher than those of low TPOAb group, low TgAb group and the control group, the levels of FT3 and FT4 were respectively lower than the low TPOAb group and low TGAb group, but there were no statistically significant on the differences between the FT3 of low TgAb and the levels of T3 and T4 of the control group, high TPOAb group, high TGAb group, low TPOAb group and low TGAb group. Conclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.

Published in	American Journal of Biomedical and Life Sciences (Volume 9, Issue 1)
DOI	10.11648/j.ajbls.20210901.12
Page(s)	10-19
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Median Urinary Iodine, Thyroid Hormone, Thyroid Autoantibody, Thyroid Disease, Hashimoto's Thyroiditis

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APA Style

Li Hongyan, Ma Jinqun, Wang Cuicui, Liu Jianfeng, Chen Yunxia, et al. (2021). Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status. American Journal of Biomedical and Life Sciences, 9(1), 10-19. https://doi.org/10.11648/j.ajbls.20210901.12

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ACS Style

Li Hongyan; Ma Jinqun; Wang Cuicui; Liu Jianfeng; Chen Yunxia, et al. Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status. Am. J. Biomed. Life Sci. 2021, 9(1), 10-19. doi: 10.11648/j.ajbls.20210901.12

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AMA Style

Li Hongyan, Ma Jinqun, Wang Cuicui, Liu Jianfeng, Chen Yunxia, et al. Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status. Am J Biomed Life Sci. 2021;9(1):10-19. doi: 10.11648/j.ajbls.20210901.12

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@article{10.11648/j.ajbls.20210901.12,
  author = {Li Hongyan and Ma Jinqun and Wang Cuicui and Liu Jianfeng and Chen Yunxia and Liu Chunyan and Hou Zhenjiang},
  title = {Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {9},
  number = {1},
  pages = {10-19},
  doi = {10.11648/j.ajbls.20210901.12},
  url = {https://doi.org/10.11648/j.ajbls.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210901.12},
  abstract = {Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (PPPPConclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.},
 year = {2021}
}

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TY  - JOUR
T1  - Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status
AU  - Li Hongyan
AU  - Ma Jinqun
AU  - Wang Cuicui
AU  - Liu Jianfeng
AU  - Chen Yunxia
AU  - Liu Chunyan
AU  - Hou Zhenjiang
Y1  - 2021/01/18
PY  - 2021
N1  - https://doi.org/10.11648/j.ajbls.20210901.12
DO  - 10.11648/j.ajbls.20210901.12
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 10
EP  - 19
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20210901.12
AB  - Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (PPPPConclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.
VL  - 9
IS  - 1
ER  -

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Author Information

Li Hongyan

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Ma Jinqun

Cangzhou People's Hospital Endocrinology, Cangzhou, China
Wang Cuicui

Department of Medical Technology, Cangzhou Medical College, Cangzhou, China
Liu Jianfeng

Cangzhou People's Hospital Endocrinology, Cangzhou, China
Chen Yunxia

Cangzhou People's Hospital Endocrinology, Cangzhou, China
Liu Chunyan

Cangzhou People's Hospital Endocrinology, Cangzhou, China
Hou Zhenjiang

Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

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APA Style

Li Hongyan, Ma Jinqun, Wang Cuicui, Liu Jianfeng, Chen Yunxia, et al. (2021). Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status. American Journal of Biomedical and Life Sciences, 9(1), 10-19. https://doi.org/10.11648/j.ajbls.20210901.12

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ACS Style

Li Hongyan; Ma Jinqun; Wang Cuicui; Liu Jianfeng; Chen Yunxia, et al. Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status. Am. J. Biomed. Life Sci. 2021, 9(1), 10-19. doi: 10.11648/j.ajbls.20210901.12

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AMA Style

Li Hongyan, Ma Jinqun, Wang Cuicui, Liu Jianfeng, Chen Yunxia, et al. Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status. Am J Biomed Life Sci. 2021;9(1):10-19. doi: 10.11648/j.ajbls.20210901.12

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@article{10.11648/j.ajbls.20210901.12,
  author = {Li Hongyan and Ma Jinqun and Wang Cuicui and Liu Jianfeng and Chen Yunxia and Liu Chunyan and Hou Zhenjiang},
  title = {Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {9},
  number = {1},
  pages = {10-19},
  doi = {10.11648/j.ajbls.20210901.12},
  url = {https://doi.org/10.11648/j.ajbls.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210901.12},
  abstract = {Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (PPPPConclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.},
 year = {2021}
}

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TY  - JOUR
T1  - Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status
AU  - Li Hongyan
AU  - Ma Jinqun
AU  - Wang Cuicui
AU  - Liu Jianfeng
AU  - Chen Yunxia
AU  - Liu Chunyan
AU  - Hou Zhenjiang
Y1  - 2021/01/18
PY  - 2021
N1  - https://doi.org/10.11648/j.ajbls.20210901.12
DO  - 10.11648/j.ajbls.20210901.12
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 10
EP  - 19
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20210901.12
AB  - Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (PPPPConclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.
VL  - 9
IS  - 1
ER  -

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